Infographics / MRI Physics

Inversion recovery timing (TI nulling: STIR/FLAIR)

A graph of longitudinal magnetisation Mz against time after a 180 degree inversion pulse. Both fat and CSF start at minus M0 and recover along Mz = M0(1 minus 2 exp(minus TI over T1)) toward plus M0. Fat has a short T1 so it crosses zero early, at a short inversion time (about 150 to 180 ms) used by STIR to null fat. CSF has a long T1 so it crosses zero late, at a long inversion time (about 2000 to 2500 ms) used by FLAIR to null CSF. Imaging at a tissue's null point, where Mz equals zero, suppresses its signal.

Inversion recovery: T1 recovery curves for fat and CSF with STIR and FLAIR null points A graph of longitudinal magnetisation Mz against time after a 180 degree inversion pulse. Both fat and CSF start at minus M0 and recover along Mz = M0(1 minus 2 exp(minus TI over T1)) toward plus M0. Fat has a short T1 so it crosses zero early, at a short inversion time (about 150 to 180 ms) used by STIR to null fat. CSF has a long T1 so it crosses zero late, at a long inversion time (about 2000 to 2500 ms) used by FLAIR to null CSF. Imaging at a tissue's null point, where Mz equals zero, suppresses its signal. Inversion recovery: T1 recovery of Mz after a 180° inversion pulse fat — short T1 (nulled early, STIR) CSF — long T1 (nulled late, FLAIR) Mz = 0 → tissue nulled +M₀ 0 −M₀ Mz time after 180° pulse — horizontal schematic, not to scale STIR — short TI nulls fat (short T1) TI ≈ 150–180 ms FLAIR — long TI nulls CSF (long T1) TI ≈ 2000–2500 ms 180° pulse at t = 0 flips Mz to −M₀, then it recovers: Mz(TI) = M₀(1 − 2e^(−TI/T1)); null (Mz = 0) at TI ≈ 0.69 × T1. TI is the 180°→90° delay and sets T1 contrast; TR is measured 180°→180°. FLAIR reads out with a T2-weighted (long TR/TE) spin echo, keeping lesions bright while CSF is suppressed.

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